The 25th century spanned the Earth years 2401 to 2500.
- Sela leads a Romulan and Hirogen fleet to Rator III and assumes control of the Romulan Star Empire.
- The Gorn Hegemony and their allies surrender to the Klingon Empire. The Klingons execute several Undine infiltrators of the Hegemony.
- The Klingons invade the Korvat Colony in the Hromi Cluster and begin forcibly removing Federation civilians. The Federation responds with a blockade, and the Federation-Klingon War officially begins.
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